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Review Articles





2021
 Fundamental insights into the interaction between telomerase/TERT and intracelular signaling pathways
Roles of telomeres and telomerase in age-related renal disease (Review)
Diabetes, metabolic disease, and telomere length Cheng et al
Telomerase Regulation: A Role for Epigenetics Dogan & Forsynth
The Relationship Between Vitamin D and Telomere/Telomerase: A Comprehensive Review Zarei et al
Telomerase as a Therapeutic Target in Cardiovascular Disease Hoffmann et al
Alternative path to telomere elongation Lee et al
The role of telomerase and viruses interaction in cancer development, and telomerase-dependent therapeutic approaches Salimi-Jeda et al
Telomere Dynamics and Telomerase in the Biology of Hair Follicles and their Stem Cells as a Model for Aging Research Stone et al
Pulmonary Fibrosis Predisposition Overview Garcia et al
TERRA Gene Expression in Gastric Cancer: Role of hTERT Vahidi & Samadani
Germline MC1R variants and frequency of somatic BRAF, NRAS, TERT mutations in melanoma: Literature review and meta-analysis Zanna et al
The Connection Between Cell Fate and Telomere Engin & Engin
Telomere Replication: Solving Multiple End Replication Problems Bonell et al
Role of Telomeres Shorterning in Artherogenesis: An Overview Yegorov et al
TERT Promoter Alterations in Glioblastoma: A Systematic Review Olympios et al
Human TERT promoter mutations as a prognostic biomarker in glioma Powter et al
hTERT, hTR, and TERT promoter mutations as markers for urological cancers detection: A systematic review Morozov et al
Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Prespectives Vaiserman & Krasnienkov
Molecular mechanisms of telomere biology disorders Grill & Nandakumar
When the Ends Justify the Means: Regulation of Telomere Addition at Double-Strand Breaks in Yeast Hoerr et al
Potential of Naturally Derived Compounds in Telomerase and Telomere Modulation in Skin Senescence and Aging Jacczak et al
Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging Gavia-García
Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases Saretzki & Wan
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization Lim & Cech
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway Shen et al
2020
 Regulation of human telomerase in homeostasis and disease
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials Relitti et al
The Solo Play of TERT Promoter Mutations Hafezi & Bercoff
Correlation between IDH, ATRX, and TERT promoter mutations in glioma Ohba et al
Structural biology of telomeres and telomerase Smith et al
Therapeutic strategies for targeting telomerase in cancer Chen et al
Telomerase reactivation is associated with hepatobiliary and pancreatic cancers Sansone et al
Telomerase and telomeres in aging theory and chronographic aging theory (Review) Razgonova et al
Telomerase Reverse Transcriptase (TERT) Regulation in Thryoid Cancer McKelvey et al
Composition and Function of Telomerase- A Polymerase Associated with the Origin of Euaryotes Schrumpofova & Fajkus
In silico design of telomerase inhibitors Baginski & Serbakowska
Telomeres and Telomerase in the Development of Liver Cancer Stroth et al
Telomeres and Telomerase in Heart Ontogenesis, Aging and Regeneration Nalobin et al
Telomerase activation in the treatment of aging or degenerative diease: a systematic review Prieto-Oliveira
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells
Potential Telomere-Related Pharmacological Targets Berel et al
Telomerase RNA processing: Implications for human health and disease Nagpal & Agarwal
The secrets of telomerase: Retrospective analysis and future prospects Kamal et al
Human Telomerase RNA: Telomerase Component or More? Rubtsova & Dontsova
POT1-TPP1 telomere length regulation and disease Aramburu et al
Telomeres and telomerase in oncogenesis Trybek et al
Telomere-related Markers for Cancer Yuan et al
Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations Amir et al
Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging Rossi & Gorospe
Telomerase: Key regulator of inflammation and cancer Wu et al
Targeting telomerase for cancer therapy Guterres & Villanueva
Modulation of telomerase expression and function by miRNAs: Anti-cancer potential Salamati et al
Telomeres and Telomere Length: A General Overview Srinivas et al
Telomere length and telomerase activity in osteoporosis and osteoarthritis Fragkiadaki et al
Therapeutic Targets in Telomerase and Telomere Biology of Cancers Prasad et al
G-Quadruplexes at Telomeres: Friend or Foe? Bryan
Crossroads of telomere biology and anticancer drug discovery Seimiya
2019
 Telomerase structures and regulation: shedding light on the chromosome end
Spectrum of TERT promoter mutations and mechanisms of activation in thyroid cancer
Telomeres and telomerase: three decades of progress Shay & Wright
The role of telomeres and telomerase in cirrhosis and liver cancer Nault et al
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics Yuan & Xu
Mitochondria, Telomeres and Telomerase Subuits Zheng et al
The telomere world and aging: Analytical challenges and future perspectives Mensà et al
Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing Liu et al
Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players Yuan et al
Structural Biology of Telomerase Wang et al
2018
 TERT promotermutation in solitary fibrous tumor
The role of TERT promoter mutations in postoperative and preoperative diagnosis and prognosis in thyroid cancer
New perspectives on telomerase RNA structure and function
Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites
Telomerase activity and telomere on stem progeny senescence
2017
 Telomerase Mechanism of Telomere Synthesis
2016
 Advances on the regulation of telomerase
Understanding TERT Promoter Mutations: A Common Path to Immortality
TERT promoter mutations in thyroid cancer Liu & Xing
Evolutionary perspectives of telomerase RNA structure and function Podlevsky & Chen
2015
 Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
2013
 Frequency of TERT promoter mutations in human cancers
Telomerase at the intersection of cancer and aging
Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme
2012
 Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications
It all comes together at the ends: telomerase structure, function, and biogenesis
Telomerase and idiopathic pulmonary fibrosis Armanios
Telomeres and telomerase in Candida albicans Yu
2011
 Telomerase and the endocrine system
Medical genetics and epigenetics of telomerase
Role of telomeres and telomerase in cancer Shay & Wright
Single-molecule analysis of telomerase structure and function Hengesbach et al
Prevalence of telomerase activity in human cancer Chen & Chen
2010
 Telomerase: structure, functions, and activity regulation
Targeting telomerase in hematologic malignancy
Imetelstat (GRN163L)-- telomerase-based cancer therapy Roth et al
Telomerase as an emerging target to fight cancer-- opportunities and challenges for nanomedicine Philippi et al
Oestrogen, telomerase, ovarian ageing and cancer Li et al
InTERTpreting telomerase structure and function Wyatt et al
2009
 Syndromes of telomere shortening
Dyskeratosis congenita, stem cells and telomeres
Targeting the telosome: therapeutic D-c implications Folini et al
Telomerase regulation in D-c hematological cancers: a matter of stemness Deville et al
Targeting critical steps of D-c cancer metastasis and recurrence using telomerase template antagonists Dikmen et al
Telomere length maintenance in stem cell populations Allen et al
Telomere maintenance: all's well that ends well Liew et al
Chromosome end maintenance by telomerase Osterhage et al
Telomerase structure paves the way for new cancer therapies Skordalakes
Advances in the understanding of dyskeratosis congenita Walne et al
The promise of telomere length, TERT/ telomerase activity and its regulation in the translocation-dependent cancer D-c ESFT; clinical challenges and utility Proctor et al
Telomere heterogeneity: taking advantage of stochastic Tomaska et al
Telomeres do the (un)twist: helicase actions at chromosome termini Chavez et al
Dyskerin, telomerase and the DNA damage response Gu et al
Telomeres and reproductive aging Keefe et al
Kleemeier Award Lecture 2008--the canary in the coal mine: telomeres and human healthspan Effros
2008
Telomere shortening and ageing of the immune system
Cytogenetics for the study of telomere function in plants Siroky
Telomeres, telomerase and senescence.
Telomere capping and cellular checkpoints: clues from ALT fruit flies Ciapponi et al
Regulation of telomere length in Drosophila Frydrychova et al
The number of dysfunctional telomeres in a cell: one amplifies; more than one translocate Tusell et al
Mechanisms of telomeric instability Baird
Telomeres, histone code, and DNA damage response Misri et al
Telomerase regulation at TERT the crossroads of cell fate Cukusi et al
Telomerase recruitment to telomeres Stern et al
Crosstalk between chromatin structure, nuclear compartmentalization, and telomere biology Gonzalez-Suarez et al
The telomeric transcriptome and SMG proteins at the crossroads Chawla et al
Telomere-associated proteins: cross-talk between telomere maintenance and telomere-lengthening mechanisms De Boeck et al
The levels of telomere-binding proteins in human TBP's tumours and therapeutic implications Cookson et al
Telomerase biogenesis: The long road before getting to the end Gallardo et al
The epidemiology of human telomeres: faults and promises Aviv
The telosome/shelterin complex and its functions Xin et al
Telomeres and telomerase in lung cancer Fernandez-Garcia et al
Telomere biology in heart failure Wong et al
Telomeric chromatin: roles in aging, cancer and hereditary disease McCord et al
G-quadruplex structure: a target for anticancer therapy and a probe for detection of potassium Chen et al
Understanding and exploiting D-c hTERT promoter regulation for diagnosis and treatment of human cancers Kyo et al
How shelterin protects mammalian telomeres Palm et al
How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex Bianchi et al
Telomeric nucleosomes: forgotten players at chromosome ends Pisano et al
Telomere maintenance in Drosophila: rapid transposon evolution at chromosome ends Villasante et al
The many faces of telomerase: emerging extratelomeric effects Bollmann
Different rates of telomere attrition in peripheral lymphocytes in a pair of dizygotic twins with hematopoietic chimerism Brüderlein et al
Actions of human telomerase beyond telomeres Cong et al
Actions of human telomerase beyond telomeres Pisano et al
ATM-like kinases and regulation of telomerase: lessons from yeast and mammals Sabourin et al
Predicted elements of telomere organization and function in Ustilago maydis Sánchez-Alonso et al
Telomere dysfunction and tumour suppression: D-c the senescence connection Deng et al
Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity Rankin et al
Telomeric nucleosomes: forgotten players at chromosome ends Pisano et al
Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity Rankin et al
Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis Cosme-Blanco et al
Telomeres: the silence is broken Azzalin et al
Telomeres in drag: Dressing as DNA damage to engage telomerase Rog et al
Telomeres and aging Aubert et al
Cyclin-dependent kinase inhibitor p16(INK4a) senes and telomerase may co-modulate endothelial progenitor cells senescence Yang et al
Telomere D-c length, telomeric proteins and genomic instability during the multistep carcinogenic process Raynaud et al
DNA damage response at functional and dysfunctional telomeres Longhese
Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks Rong
Regulation of telomerase and telomeres: human tumor viruses take control Bellon et al
The role of telomere biology in bone marrow failure and other disorders Savage et al
Cellular senescence, cardiovascular risk, and CKD: a review of established and hypothetical interconnections Tsirpanlis
Drosophila telomeres: an exception providing new insights Mason et al
2007
Telomere uncapping and alternative lengthening of telomeres
Telomerase, senescence and ageing Shawi et al
Telomere and adaptive immunity Weng
Telomere length inheritance and aging
Assessing ageing of individual T lymphocytes: mission impossible?
Ageing and atherosclerosis: Mechanisms and therapeutic options Costopoulos et al
Telomere stability and telomerase in mesenchymal stem cells Serakinci et al
Telomere length assessment: biomarker of chronic oxidative stress? Houben et al
Anticancer therapy targeting telomeres and telomerase: current status Parkinson et al
Telomeres: hallmarks of radiosensitivity Ayouaz et al
Dyskeratosis congenita: a genetic disorder of many faces Kirwan et al
Telomere dysfunction and telomerase activation in cancer--a pathological paradox? Calcagnile et al
Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family Dwyer et al
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Passos et al
Role of telomeres in vascular senescence Minamino et al
Studying telomeres in a longitudinal population based study De Meyer et al
Telomere dysfunction, genome instability and cancer Cheung et al
Telomeres II Baird
Telomeres, senescence, and hematopoietic stem cells Zimmermann et al
Budding yeast with human telomeres: a puzzling structure Auriche et al
Pharmacological intervention strategies for affecting telomerase activity: future prospects to treat cancer and degenerative disease Tárkányi et al
Telomere shortening and ageing Jiang et al
Alternative lengthening of telomeres (ALT) and chromatin: is there a connection? Nittis et al
Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene Li et al
Targeting ALT: the role of alternative lengthening of telomeres in pathogenesis and prevention of cancer Bollmann
Telomere dysfunction in hypertension Fuster et al
Endings in the middle: current knowledge of interstitial telomeric sequences Lin et al
Human diseases of telomerase dysfunction: insights into tissue aging Garcia et al
Cryptic telomere imbalance: a 15-year update Ledbetter et al
Alternative ends: telomeres and meiosis Saint-André et al
Energetics of quadruplex-drug recognition in anticancer therapy Pagano et al
How telomeres are replicated Gilson et al
Telomeres and DNA double-strand breaks: ever the twain shall meet? Bailey et al
Telomeric position effect: from the yeast paradigm to human pathologies? Ottaviani et al
Telomere dynamics in human cells Baird
Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complex Vulliamy et al
Tankyrase function at telomeres, spindle poles, and beyond Hsiao et al
Targeting telomeres and telomerase De Cian et al
Targeting the limitless replicative potential of cancer: the telomerase/telomere pathway Kelland
Telomeres and telomerase in leukaemia and lymphoma Davison
Protection against chromosome degradation at the telomere Grandin et al
Telomere instability and cancer Londoño-Vallejo et al
Telomere length profiles in humans: all ends are not equal Gilson et al
Telomerase: a crucial player in HTLV-I-induced human T-cell leukemia Bellon et al
The cancer-aging interface and the significance of telomere dynamics in cancer therapy Tallen et al
Telomere regulation and function during meiosis Siderakis et al
Telomere dynamics: the means to an end Matulić et al
Extension of cell life span using exogenous telomerase Kang et al
Telomere length analysis Canela et al
Harnessing telomerase in cancer therapeutics Fakhoury et al
Structure of telomeric chromatin in Drosophila. Shpiz et al
Mutations of telomerase complex genes linked to bone marrow failures Yamaguchi
Telomerase and its potential for therapeutic intervention Phatak et al
Replication and protection of telomeres Verdun et al
Telomere biology of trypanosomatids: beginning to answer some questions Lira et al
Telomere maintenance in sarcomas Johnson et al
Soothing the watchman: telomerase reduces the p53-dependent cellular stress response Beliveau et al
Telomere biology of pediatric cancer Tabori et al
Telomere shortening & metabolic/vascular diseases Balasubramanyam et al
The cell division cycle puts up with unprotected telomeres: cell cycle regulated telomere uncapping as a means to achieve telomere homeostasis Vodenicharov et al
The human telomere and its relationship to human disease, therapy, and tissue engineering Moon et al
Telomeres and telomerase: Biological and clinical importance in dogs Nasir
Composition of plant telomeres Zellinger et al
The epigenetic regulation of mammalian telomeres Blasco
Telomere and telomerase in stem cells Hiyama et al
WRN at telomeres: implications for aging and cancer Multani et al
Telomerase: going beyond the ends De Semir et al
Telomerase expression in lung preneoplasia and neoplasia Lantuéjoul et al
Telomeres and telomerase as targets for cancer therapy Zimmermann et al
Telomeres in meiotic recombination: the yeast side story Joseph et al
Regulation of telomere movement by telomere chromatin structure Pandita et al
Telomeres and aging-related meiotic dysfunction in women Keefe et al
DNA damage responses in neural cells: Focus on the telomere Zhang et al
Hallmarks of telomeres in ageing research Shay et al
Telomeres rather than telomerase a key target for anti-cancer therapy? Boukamp et al
2006
Telomerase RNA levels limit the telomere length equilibrium
Telomerase induction in T cells: a cure for aging and disease? Effros
Telomere biology and cardiovascular disease Fuster et al
Telomeres and telomerase in stem cells during aging and disease Ju et al
Telomeres Baird
Short telomeres: cause or consequence of aging? Hornsby
Human telomere biology: pitfalls of moving from the laboratory to epidemiology Aviv et al
Telomeres and human somatic fitness Aviv
Themes in ssDNA recognition by telomere-end protection proteins Croy et al
Telomere length dynamics in normal hematopoiesis and in disease states characterized by increased stem cell turnover Brümmendorf et al
Telomeres and telomerase. A survey about methods and recent advances in cancer diagnostic and therapy Weise et al
Targeting telomerase Siddiqa et al
Telomeres: prognostic markers for solid tumors Bisoffi et al
Intra-allelic mutation at human telomeres Britt-Compton et al
Are mouse telomeres going to pot? Baumann
Telomeres: cancer to human aging Stewart et al
Dyskeratosis congenita Vulliamy et al
The role of the nonhomologous end- joining DNA double-strand break repair pathway in telomere biology Riha et al
Telomerase as a clinical target: current strategies and potential applications Fleisig et al
The role of DNA damage response proteins at telomeres--an "integrative" model. Slijepcevic
Chromosomal telomere attrition as a mechanism for the increased risk of epithelial cancers and senescent phenotypes in type 2 diabetes Sampson et al
Diagnostics, prognostic and therapeutic exploitation of telomeres and telomerase in leukemias Deville et al
Telomeres and chromosome instability Murnane
Telomerase therapeutics for cancer: challenges and new directions Shay et al
The structure and function of telomerase reverse transcriptase Autexier et al
Break-induced replication and recombinational telomere elongation in yeast McEachern et al
Inside the mammalian telomere interactome: regulation and regulatory activities of telomeres Songyang et al
Telomere length homeostasis Hug et al
RNA interference has a role in regulating Drosophila telomeres Casacuberta et al
The telomere theory of reproductive senescence in women Keefe et al
Molecular basis for the cellular senescence program and its application to anticancer therapy Katakura
Structure and function of telomerase RNA Theimer et al
Telomeres, chromosome instability and cancer Bailey et al
The maintenance and masking of chromosome termini Bertuch et al
Telomeres and telomerase in cancer stem cells Ju et al
Repairing subtelomeric DSBs at the nuclear periphery Taddei et al
The role of telomeres and telomerase in the pathology of human cancer and aging Shin et al
Telomeres and telomerase: Pharmacological targets for new anticancer strategies? Pendino et al
Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology Meeker
Novel roles for telomerase in aging Geserick et al
Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations Bolzán et al
Telomeres and telomerase as targets for anticancer drug developmen Olaussen et al
Telomeres, immune aging and autoimmunity Goronzy et al
The telomeric PARP, tankyrases, as targets for cancer therapy Seimiya
The significance of telomeric aggregates in the interphase nuclei of tumor cells Mai et al
Telomere dynamics in genome stability Bhattacharyya et al
New pieces of the pathogenetic mosaic in inflammatory bowel disease Vieth et al
Aneuploidy, stem cells and cancer Pathak et al
2005
Telomeres and telomerase biology in vertebrates: progress towards a non-human model for replicative senescence and ageing
Do telomere dynamics link lifestyle and lifespan? Monaghan et al
Use of telomerase to create bioengineered tissues
Telomerase inhibition and cancer: might platinum based drugs have a future as anti-telomerase pharmacological approach? Colangelo et al
The telomere length dynamic and methods of its assessment Lin et al
Role of HSPs and telomerase in radiotherapy Pandita
Do telomeres ask checkpoint proteins: "gimme shelter-in"? Weinert
Aging of mesenchymal stem cells Sethe et al
Telomeres, telomerase and oral cancer (Review) Sebastian et al
Fine-tuning the chromosome ends: the last base of human telomeres Sfeir et al
Telomerase: is it the future diagnostic and prognostic tool in human cancer? Mabruk et al
The first molecular details of ALT in human tumor cells Muntoni et al
Dyskeratosis congenita: a disorder of defective telomere maintenance? Walne et al
p16INK4a as a second effector of the telomere damage pathway Jacobs et al
Shelterin: the protein complex that shapes and safeguards human telomeres de Lange
The concept of telomeric non-reciprocal recombination (TENOR) applied to human fibroblasts grown in serial cultures: concordance with genealogical data Hasenmaile et al
Telomeres and human disease: ageing, cancer and beyond Blasco
Telomere maintenance, function and evolution: the yeast paradigm Teixeira et al
The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes Horn et al
Plasmodium telomeres and telomerase: the usual actors in an unusual scenario Figueiredo et al
Making the most of a little: dosage effects in eukaryotic telomere length maintenance Harrington
Telomeres in evolution and evolution of telomeres Fajkus et al
Telomere-specific non-LTR retrotransposons and telomere maintenance in the silkworm, Bombyx mori Fujiwara et al
Two retrotransposons maintain telomeres in Drosophila Pardue et al
Drosophila telomeres: the non-telomerase alternative Melnikova et al
Euchromatic and heterochromatic domains at Drosophila telomeres Biessmann et al
The importance of the telomere and telomerase system in hematological malignancies Ram et al
Telomere attrition as ageing biomarker Bekaert et al
The mechanism of telomere protection: a comparison between Drosophila and humans Cenci et al
Hormones and growth factors regulate telomerase activityin ageing and cancer Bayne et al
The pleiotropy of telomerase against cell death. Mol Cells Sung et al
Ku: a multifunctional protein involved in telomere maintenance Fisher et al
Telomeres: what's new at your end? LeBel et al
Telomere maintenance and tumorigenesis: an "ALT"ernative road Stewart
Telomere and telomerase dynamics in human cells Hahn
Telomeres, telomerase and malignant transformation Opitz
Telomeres, crisis and cancer Greenberg
Telomerase therapeutics for degenerative diseases Harley
Telomeres as biomarkers for ageing and age-related diseases von Zglinicki et al
Telomere dynamics in response to chemotherapy Beeharry et al
Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance Mason et al
Telomere induced senescence: end gamesignaling Chang
Modeling premature aging syndromes with the telomerase knockout mouse Chang
Telomere induced senescence: end game signaling Hezel et al
In the end, it's all structure Crabbe et al
Mitochondria, telomeres and cell senescence Passos et al
Chromosome ends: different sequences may provide conserved functions Louis et al
Telomerase: a potential therapeutic target for cancer Fletcher
The longevity gender gap: are telomeres the explanation? Aviv et al
Distinct phenotype associated with a cryptic subtelomeric deletion of 19p13.3-pter Archer et al
The role of microglial cellular senescence in the aging and Alzheimer diseased brain Flanary
Modeling aging and cancer in the telomerase knockout mouse Chang
New developments in telomere length analysis Baird
Dyskeratosis congenita: telomerase, telomeres and anticipation Marrone et al
In vivo regulation of telomerase activity and telomere length Hathcock et al
Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer Artandi et al
Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics--current status and future prospects Kelland et al
Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation Tarsounas et al
Telomere biology: integrating chromosomal end protection with DNA damage response Flanary et al
Telomerase: regulation, function and transformation Dong et al
Aging, telomeres, and atherosclerosis Edo et al
Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging Blasco
Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for sir-mediated repression Taddei et al
Telomere length regulation during cloning,embryogenesis and ageing Schaetzlein et al
Telomere dysfunction in aging and cancer Gilley et al
Cancer and aging: the importance of telomeres in genome maintenance Rodier et al
Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging Hofer et al
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors Campisi
Techniques in plant telomere biology Fajkus et al
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions Blackburn
Subtelomeric rearrangements as neutral genomic polymorphisms Hengstschläger et al
The telomerase cycle: normal and pathological aspects Brunori et al
Connecting mitotic instability and chromosome aberrations in cancer--can telomeres bridge the gap? Gisselsson et al
Telomere-related genome instability in cancer de Lange
2004
Analysis of telomere length and telomerase activity
Telomeres and human aging: facts and fibs
Dyskeratosis congenita: molecular insights into telomerase function, ageing and cancer
Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation?
Senescence and functional failure in hematopoietic stem cells
Telomeres, telomerase, and tumorigenesis--a review
Chromosome rearrangements resulting from telomere dysfunction and their role in cancer
Senescence and immortalization: role of telomeres and telomerase
Telomeres, telomerase and cancer: an endless search to target the ends Satyanarayana et al
G-quadruplex interacting agents targeting the telomeric G-overhang are more than simple telomerase inhibitor Riou
Does the reservoir for self-renewal stem from the ends? Harrington
Telomerase as a new target for the treatment of hormone-refractory prostate cancer Biroccio et al
Telomeres and telomerase: a dual role in hepatocarcinogenesis Satyanarayana
Telomere biology in mammalian germ cells and during development Bekaert et al
Telomere dysfunction in genome instability syndromes Callén et al
Telomere length heterogeneity and chromosome instability Londoño-Vallejo
Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma Lechel et al
Heterozygous telomerase deficiency in mouse and man: when less is definitely not more Mason et al
Telomerase in breast cancer: a critical evaluation Baykal et al
Measuring vertebrate telomeres: applications and limitations Nakagawa et al
Telomeres and telomerase: a modern fountain of youth? de Magalhães et al
Telomere maintenance in clinical medicine Ulaner
Strand-specific fluorescence in situ hybridization: the CO-FISH family Bailey et al
Telomeres: not all breaks are equal Purdy et al
Functional links between telomeres and proteins of the DNA-damage response d'Adda di Fagagna et al
Telomeres, telomerase, and apoptosis de Lange
Telomere length heterogeneity and chromosome instability Mondello et al
Telomeres and the DNA damage response: why the fox is guarding the henhouse Maser et al
Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancers de Grey et al
Telomeres and telomerase in the fetal origins of cardiovascular disease: a review Demerath et al
Regulation of telomerase by telomeric proteins Smogorzewska et al
Telomere length and telomerase activity: variations with advancing age and potential role in childhood malignancies Polychronopoulou et al
Alternatives to telomerase: keeping linear chromosomes via telomeric circles Tomaska et al
A mouse model of Werner Syndrome: what can it tell us about aging and cancer? Chang
DNA and telomeres: beginnings and endings Bailey et al
Telomeres are double-strand DNA breaks hidden from DNA damage responses Shay et al
Telomeres and DNA damage checkpoints Viscardi et al
Mechanisms of cellular senescence in human and mouse cells Itahana et al
Those dam-aged telomeres! Harrington
Hallmarks of senescence in carcinogenesis and cancer therapy Shay et al
Telomeres and telomerase Chan et al
Telomeres and chromosomal instability Mathieu et al
The role of telomeres in skin aging/photoaging Kosmadaki et al
Telomere length variation and anemia telomerase activity expression in patients with congenital and acquired aplastic anemia Polychronopoulou et al
Telomeres and cardiovascular disease: does size matter? Serrano et al
Telomere biology of human hematopoietic stem cells Elwood
Polypeptide components of telomere nucleoprotein complex Kuimov
Culture models of human mammary epithelial cell breast transformation Stampfer et al
Beginning to understand the end of the chromosome Cech
Indecent exposure: when telomeres become uncappede Ferreira et al
Telomeres, stem cells, senescence, and cancer Sharpless
Recent advances in telomere biology: implications for human cancer Meeker
Is there a link between telomere maintenance and radiosensitivity? Slijepcevic
2003
Telomerase, telomerase inhibition, and cancer
Telomeres, telomerase, and hematopoietic stem cell biology
Replicative senescence and the art of counting
Telomerase as a novel and potentially selective target for cancer chemotherapy
Telomere dynamics unique to meiotic prophase: formation and significance of the bouquet Bass
Composition and conservation of the telomeric complex Kanoh et al
Protecting the terminus: t-loops and telomere end-binding proteins Wei et al
Retrotransposons provide an evolutionarily robust non-telomerase mechanism to maintain telomeres Pardue et al
Telomere higher-order structure and genomic instability Fletcher
The evolving role of telomerase inhibitors in the treatment of cancer Mokbel
Is there a link between telomere maintenance and radiosensitivity? Slijepcevic
Is there a link between telomere maintenance and radiosensitivity? Slijepcevic
Mammalian telomeres and telomerase: why they matter for cancer and aging Blasco
Dyskeratosis congenita: its link to telomerase and aplastic anaemia Dokal et al
Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways Lydall
Yeast telosome complex: components and their functions Dmitriev et al
The role of telomerase activation in the regulation of vascular smooth muscle cell proliferation Minamino et al
Telomere maintenance and DNA replication: how closely are these two connected? Chakhparonian et al
Telomerase inhibitors in cancer therapy: current status and future directions Incles et al
Telomerase and cancer Testorelli
Mouse models for telomere and telomerase biology Cheong et ak
Telomerase and the aging heart Heist et al
Telomeres in the chicken: genome stability and chromosome ends Delany et al
Telomeres: a diagnosis at the end of the chromosomes De Vries et al
Telomeres and telomerase in aging, regeneration and cancer Djojosubroto et al
Evolving views of telomerase and cancer Blasco et al
Evolving views of telomerase and cancer Blasco et al
Fingering the ends: how to make new telomeres Cristofari et al
An introduction to telomeres and telomerase Bibby
Telomerase and breast cancer: from diagnosis to therapy Mokbel et al
. Telomere structure, function and maintenance in Arabidopsis Riha et al
Molecular manifestations and molecular determinants of telomere capping Blackburn et al
Telomere repeat binding factors: keeping the ends in check Karlseder
Telomeres in cancer and aging: lessons from the mouse Blasco
Telomere-driven genomic instability in cancer cells Desmaze et al
Telomerase and tumorigenesis Masutomi et al
Alternative lengthening of telomeres, telomerase, and cancer Masutomi et al
Telomerase and tumorigenesis Reddel
Telomerase as a target for cancer immunotherapy Nguyen et al
Role of telomeres and telomerase in the pathogenesis of human cancer Hahn
Mechanisms of replication and telomere resolution of the linear plasmid prophage N15 Ravin
The age of cancer: telomeres, checkpoints, and longevity DePinho et al
Role of Pin2/TRF1 in telomere maintenance and cell cycle control Zhou et al
2002
 Telomere architecture. Rhodes et al
Unusual DNA conformations: implications for telomeres.
Targeting human telomerase by antisense oligonucleotides and ribozymes.
The 'other' telomerase inhibitors: non-G-quadruplex interactive agent, non-antisense, non-reverse transcriptase telomerase inhibitors.
Beltz
Telomerase inhibitors as anticancer therapy.
Telomere shortening in hematopoietic stem cell transplantation: a potential mechanism for late graft failure?
Mouse models to study the role of telomeres in cancer, aging and DNA repair.   Blasco
Telomeres, sex, reactive oxygen species, and human cardiovascular aging.  Aviv
The significance of telomerase activation and cellular immortalization in human cancer.   Newbold
Telomeres: the molecular events driving end-to-end fusions.   Bertuch
Are Drosophila telomeres an exception or the rule?   Louis
Design of telomerase inhibitors for the treatment of cancer.  Cairns et al
Role of telomere in endothelial dysfunction in atherosclerosis. Minamino et al
Chronology versus biology: telomeres, essential hypertension, and vascular aging.   Aviv
Telomeres in T and B cells.   Hodes et al
Human telomerase and its regulation.   Cong et al
Telomeres in mammalian male germline cells.   Zalenskaya et al
Telomeres and telomerases as drug targets.  Rezler et al
Historical claims and current interpretations of replicative aging.   Wright et al
The disparity between human cell senescence in vitro and lifelong replication in vivo.  Rubin
Telomere lengthening in telomerase-negative cells: the ends are coming together.   Scheel et al
Lundblad V. Mechanisms of chromosome-end protection.   Cervantes et al
Telomere maintenance as a target for anticancer drug discovery.   Neidle et al
Telomerase as a diagnostic and therapeutic target for cancer.   Doyle et al
Telomerase inhibition and the future management of head-and-neck cancer.   McCaul et al
Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?   Allsopp et al
Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans.   Bénard et al
Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.  Fajkus et al
Genes, telomeres and mammalian ageing.   Goyns
Telomerase in brain tumors.   Falchetti et al
Replicative aging, telomeres, and oxidative stress.  Saretzki et al
 Prospects for anti-neoplastic therapies based on telomere biology. Stewart et al
Signaling on telomerase: a master switch in cell aging and immortalization. Li et al
Telomeres, X-inactivation ratios, and hematopoietic stem cell transplantation in humans: a review.   Thornley et al
Telomeres and telomerase in human health and disease.   Tzukerman et al
Telomeres, telomerase, and stability of the plant genome.  McKnight et al
Telomerase and telomeres: from basic biology to cancer treatment.  Helder et al
The complex structure and dynamic evolution of human subtelomeres.   Mefford et al
Natural and pharmacological regulation of telomerase.   Mergny et al
Telomeres and telomerase in hematologic neoplasia.   Ohyashiki et al
Senescence: does it all happen at the ends?  Stewart et al
ATM function and telomere stability. Pandita
Alternative lengthening of telomeres in mammalian cells.  Henson et al
Many ways to telomere dysfunction: in vivo studies using mouse models.   Goytisolo et al
A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation.   Ford et al
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin.   Chan et al
Protection of mammalian telomeres.   de Lange
Telomere maintenance without telomerase.   Lundblad
Telomeres, aging and cancer: in search of a happy ending.  Kim et al
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again.   Forsyth et al
Telomerase in cancer and aging.   Granger et al
2001
 Telomerase inhibitors for the treatment of cancer: the current perspective.   Perry et al
Measuring telomerase activity for the early detection of cancer.  Blechner et al
Ageing mechanisms: the role of telomere loss.   Boukamp
Telomeres at the chromosome X(p) might be critical in limiting the proliferative potential of human cells.   Hao et al
Cellular senescence, cancer and aging: the telomere connection.   Campisi et al
Telomerase: biological function and potential role in cancer management. Chatziantoniou  
Telomeric sequences, radiation sensitivity and genomic instability.   Bouffler et al
The circle is broken: telomere resolution in linear replicons.   Kobryn et al
Telomerase in endocrine and endocrine-dependent tumors. Orlando et al
Switching and signaling at the telomere.   Blackburn
Plasmodium telomeres: a Virus? pathogen's perspective.  Scherf et al
Telomerase in urological malignancy.  Orlando et al
Telomeres and telomerase: basic science implications for aging.  Ahmed et al
Telomerase in human tumors: molecular diagnosis and clinical significance.   Dahse et al
Telomerase: biology and phase I trials.
Telomeres and replicative senescence: Is it only length that counts?   von Zglinicki
Telomeres.
Turning telomeres off and on.   Dubrana et al
Telomere biology in human aging and aging syndromes.   Klapper et al
Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective.   Mattson et al
How long should telomeres be?   Aviv et al
Telomerase and cancer.   Shay et al
Telomeric chromatin: replicating and wrapping up chromosome ends.   Shore
Telomerase activation, cellular immortalization and cancer.   Hahn et al
Telomerase inhibitors.   White et al
Targeted inhibition of telomerase in human cancer: will it be a double-edged sword?
Telomeres, replicative senescence and human ageing.   Kipling
Telomeres: the time factor in essential hypertension.  Aviv et al
Telomerase and breast cancer.
Ageing and cancer: the telomere and telomerase D-c connection.   Shay et al
Alternative lengthening of telomeres in human cells.   Reddel et al
Telomeres and telomerase: implications for cancer aging and aging.  Shay et al
2000
 Telomere maintenance mechanisms as a target for drug development.   Bearss et al
Telomerase and human tumorigenesis.   Stewart et al
Senescence and immortalization of human cells.
Control of telomere elongation and telomeric silencing in Drosophila melanogaster.   Mason et al
Drosophila telomere transposons: genetically active elements in heterochromatin.   Pardue et al
Drosophila telomeric transgenes provide insights on mechanisms of gene silencing.   Wallrath
Telomerase and the cellular lifespan: implications of the aging process.   Ostler et al
Telomerase, immortality and cancer.  Krupp et al
Telomeres and their control.   McEachern et al
Telomere length maintenance in aging and carcinogenesis.   Aragona et al
Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging?   Jennings et al
The polymorphic telomeres of the African Trypanosome trypanosoma brucei.   Rudenko
Positive and negative regulation of telomerase access to the telomere.   Evans et al
Telomerase inhibitors: targeting the vulnerable end of cancer?  Kelland
Repair of telomeric DNA prior to replicative senescence.   Lansdorp
Telomeres, telomerase and cancer: an up-date.  Dhaene et al
Role of telomerase in normal and cancer cells.   Meyerson
Telomerase activity in cancer as a diagnostic and therapeutic target.  Kyo et al
DNA ends: maintenance of chromosome termini versus repair of double strand breaks.   Lundblad
Role of oxidative stress in telomere length regulation and replicative senescence.  von Zglinicki
Perfect endings: a review of subtelomeric probes and their use in clinical diagnosis.   Knight et al
Mammalian telomeres and telomerase.   Collins
DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugs.   Raymond et al
Dyskeratosis congenita, telomeres and human ageing.  Marciniak et al
Telomeres, telomerase, and cancer.   Buys
Telomerase: a therapeutic target for the third millennium?  Lavelle et al
. Telomere transitions in yeast: the end of the chromosome as we know it.   Cooper
Telomerase and mammalian ageing: a critical appraisal.   Goyns et al
G-Quadruplex DNA as a target for drug design.   Kerwin
Role of telomerase in cell senescence and oncogenesis.   Urquidi et al
Telomerase in cutaneous carcinogenesis.   Ueda
A critical role for telomeres in suppressing and facilitating carcinogenesis.   Artandi et al
Telomeres and HIV disease.  Effros
Telomeres, telomerase, and cancer: life on the edge of genomic stability.  Oulton et al
Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease.  Smith et al
Telomeres, telomerase, and myc. An update.   Cerni
1999
 Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase.   Vaziri et al
Studies of the molecular mechanisms in the regulation of telomerase activity.  Liu
Telomerase as a possible target for anticancer therapy.   Autexier
The roles of telomeres and telomerase in cellular immortalization and the development of cancer.
Telomerase as an anti-cancer drug target: will it fulfil its early promise?
Telomerase as an anti-cancer target: current status and future prospects.
Telomeres and telomerase: at the end, it all comes together.   Evans et al
Role of telomerase in cellular proliferation and cancer.   Holt et al
Telomerase and the maintenance of chromosome ends.   Bryan et al
Telomeres do D-loop-T-loop.   Greider
Telomeres and telomerase: broad effects on cell growth.   Price
Telomeres and essential hypertension.   Aviv et al
Cytological and functional aspects of telomere maintenance.   Dandjinou et al
Telomere maintenance mechanisms and cellular immortalization.  Colgin et al
Telomerase activation. One step on the road to cancer?  Greider
Telomeres: structure of a chromosome's aglet.  Gottschling et al
Cellular senescence and cancer.   Wynford-Thomas
1998
Telomeres: influencing the rate of aging.
Role of the telomeric DNA-binding protein TRF2 in the stability of human chromosome ends.   Ancelin et al
Telomeres and telomerase in endocrine pathology.
Telomerase in cancer: clinical applications.
Telomere length regulation--a view from the individual chromosome perspective.  Slijepcevic
The implication of telomerase activity and telomere stability for replicative aging and cellular immortality (Review).   Engelhardt et al
Telomeres--unsticky ends.   Shore
The role of telomeres in ageing and cancer.   Mera
Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells.   Sedivy
Meiotic telomeres: a matchmaker for homologous chromosomes.   Hiraoka
Telomeres, hidden mosaicism, loss of heterozygosity, and complex genetic traits.   Aviv et al
Telomeres: moonlighting by DNA repair proteins.   Weaver
Telomeres, the nucleolus and aging.  Johnson et al
Telomerase and the aging cell: implications for human health.  Fossel
Telomerase and chromosome end maintenance.   Lingner et al
Telomeres and HIV-1 infection: in search of exhaustion.  Wolthers et al
Telomerase activity in cancer: a magic bullet or a mirage
Telomeres and senescence: the history, the experiment, the future.   Greider
Telomere structure, replication and length maintenance.  Muniyappa et al
Telomere tales: chromatin, telomerase and telomere function in Saccharomyces cerevisiae.   Lowell et al
Chromosome healing, telomere capture and mechanisms of radiation-induced chromosome breakage.   Slijepcevic et al
1997
Chromosome ends: all the same under their caps.
Immortalized cells with no detectable telomerase activity. A review.
Telomere functions. A review.
Saccharomyces cerevisiae telomeres.
Telomerase is an unusual RNA-containing enzyme. A review.
The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review.   Blackburn
Mortality and immortality at the cellular level. A review.  Hayflick
Preclinical and clinical strategies for development of telomerase and telomere inhibitors.  Sharma et al
Mammalian telomerase: catalytic subunit and knockout mice.   Kipling
Telomeres, senescence and cellular radiation response.   Crompton
Telomere length regulation: getting the measure of chromosome ends.   Shore
A telomerase mutant defective in sister chromatid separation at mitosis.   Nakaseko et al
Telomere maintenance without telomerase.   Biessmann et al
Telomeres, not the end of the story.  Gotta et al
Telomeres and telomerase: biological and clinical importance.  Dahse et al
Reflections on telomeres, growth, aging, and essential hypertension.   Aviv et al
Telomeres, telomerase and chromosome stability.   Preston
Telomere structure and telomerase expression during mouse development and tumorigenesis.   Kipling
. Telomeres and telomerase in normal and malignant haematopoietic cells.  Norrback et al
Telomere dynamics and telomerase activity in in vitro immortalised human cells.   Bryan et al
Multiple pathways for the regulation of telomerase activity.  Holt et al
The implications of telomerase biochemistry for human disease.   Morin
Multiple pathways to cellular senescence: role of telomerase repressors. Oshimura et al
Telomere dynamics and cytogenetic changes in human hematologic neoplasias: a working hypothesis.   Ohyashiki et al
Replicative senescence and cell immortality: the role of telomeres and telomerase.  Chiu et al
Telomere crisis, the driving force in cancer cell evolution.  Ishikawa
Telomeres in the haemopoietic system.   Lansdorp et al
Repair and processing events at DNA ends.   Lindahl et al
Mouse models for the study of telomerase.   Blasco et al
Human ageing and telomeres.   Harley
Telomerase and the chromosome end replication problem.  Cech et al
The telomere and telomerase: how do they interact?   Blackburn et al
Telomeres terminating with long complex tandem repeats.   Kamnert et al
Evolutionary links between telomeres and transposable elements.  Pardue et al
Telomerase, checkpoints and cancer.   Harley et al
Applications of telomerase in urologic oncology.  Landman et al
Telomerase activation and cancer.   Klingelhutz
1996
Genetic regulation of telomerase in a multiple pathways model to cellular senescence.
Technical improvement in determining telomerase activity in hematologic neoplasias: a possibility of single cell determination of telomerase activity.
Telomeres and telomerase in normal and malignant haematologic cells.  Leber et al
Agents that target telomerase and telomeres.  Raymond et al
The involvement of telomeric sequences in chromosomal aberrations.   Bouffler et al
The roles of telomeres and telomerase in cell life span.   Counter
Telomerase and cancer: revisiting the telomere hypothesis.  Autexier et al
Telomeres and telomerase in human hematologic neoplasia.   Yamada
Telomeres and telomerase in human leukemias.  Shay et al
. The role of telomeres and telomerase in human cancer.  Balasubramanian et al
Structure and function of telomerase.   Collins
Chromosome healing: spontaneous and programmed de novo telomere formation by telomerase.   Melek et al
Telomeres, telomerase, and the cell cycle.   Buchkovich
Telomeres, p53 and cellular senescence.   Wynford-Thomas
Telomerase as a therapeutic target.   Huminiecki
Telomerase activity in human cancer.   Shay et al
Telomere length regulation.   Greider
Telomerase and cancer.   Harley et al
From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging.   Vaziri et al
. Models of initiation of replicative senescence by loss of telomeric DNA.  Allsopp
Telomeres, telomerase and cancer: is the magic bullet real?  Sharma et al
1995
Telomeres: beginning to understand the end.
Aging and cancer: are telomeres and telomerase the connection?
Telomeres, telomerase, and immortality.
Telomere structure and function.
Telomeres and telomerase in aging and cancer.
Chromosomal instability and alteration of telomere repeat sequences.
Telomere dynamics and telomerase activation in tumor progression: prospects for prognosis and therapy.   Healy
1994
Telomeric repeat sequences.
Mammalian telomere dynamics: healing, fragmentation shortening and stabilization.
1993
Telomeres and telomerases.
Telomeric DNA binding proteins.
Aging, healing, and the metabolism of telomeres.   Broccoli et al
Telomeres and their possible role in chromosome stabilization.  Day et al
1992
Centromeres and telomeres.
Beginning or end? Telomere structure, genetics and biology.
1991
Telomeres-- what's new at the end?
Telomeres.
Telomeres.  Greider
Structure and function of telomeres.   Blackburn
Telomere loss: mitotic clock or genetic time bomb?   Harley
1990
Telomeres, Telomerase, and Senescence
Telomeres: structure and synthesis.
Telomere cloning and mammalian chromosome analysis.   Brown et al
How does the end begin? Formation and maintenance of telomeres in ciliates and yeast.   Zakian et al
Telomeres and their synthesis.   Blackburn
1989
Human telomeres: fusion and interstitial sites.
Structure and function of telomeres.