10        20        30        40        50        60        70        80        90       100       110       120                    
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                                      
structure                                                                                                                                             
Kluyveromyces lactis         ------------------------------------------------------------------------------------------------------------------------ 
Kluyveromyces wickerhamii    ------------------------------------------------------------------------------------------------------------------------ 
Kluyveromyces nonfermentans  ------------------------------------------------------------------------------------------------------------------------ 
Kluyveromyces marxianus      AAUUGUAUACUUUUUAAACAACCUAAACAUGUUGUUACGUUCUAUUAUGUUCAGUAACAAUAUAGACAAUUUACCCUGCGUGUUCGAUUCUAUUUGCCAAAGCCUAGAGAGUGAUUGAGG 
Kluyveromyces dobzhanskii    ------------------------------------------------------------------------------------------------------------------------ 
Kluyveromyces aestuarii      ------------------------------------------------------------------------------------------------------------------------ 

                                     130       140       150       160       170       180       190       200       210       220       230       240           
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                                      
structure                                                                                                                                             
Kluyveromyces lactis         --GAAUAUAUGAUGGGUGCGGAAUCACGAUCGGUAUUUGUGUGAUGCAAUUUCUGGGGUGGUAAGGACCAGUGCCACACUUGGGUUUGAUUUUCCUCUCAUCGAGUUUCGUGUGCGCAUG 
Kluyveromyces wickerhamii    --AAAAUUUACUGCGAUCUCAACGAACAUAAGCUACUAAAUCUAUUUCAAUUAUUCCAAAACUUAUUUCACGAUGGGAACAAGGAGGCCUUUGGUAGAUCUGGUUGCUUACGAGGAGGUA 
Kluyveromyces nonfermentans  ---------------------------------------------------------------GUAAAGAAGAUGUGUUAGGUUUACAACGCUCUUCUCAGCAUUGUAUUGAAGUUUGUU 
Kluyveromyces marxianus      UGGUUAGGACCAGUACCACGUAUGAGACGUGUUUAACUUUUUCCAAAUGCUGACAAGGUAUAUGUCUCGUAUUUCCCUGACGUUCUCUUUACGCCUGGGAAUUGACUGAGUGGACACUC- 
Kluyveromyces dobzhanskii    -GAACUCCAUGAGUUCGUAAUCAGCAAGGAUUGUGGUAUUAUUUGCUGAAAGACGAAGUGUGAACGAAGUUUGAGGUGGUAAGGACCAGUGCCAUGCUUGAGUGUUUCUUUCUGAGUUUU 
Kluyveromyces aestuarii      -------------------------------------------------------AGCAAAGCAUUUGAAAGCUGAUUUGAAUUUCUAUCGUUCUUUUCAAAACUUCAUUGAAGAUAGUU 

                                     250       260       270       280       290       300       310       320       330       340       350       360           
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                                      
structure                                                                                                                                             
Kluyveromyces lactis         UUCGUCUCUCACAUCGAGUUAUACUCUCAUCUUCUAUACAUUAGAAGGAUGCAUCAGCAGUUUGAUCUGCUGAAAGAGUUCAUACACCCAAUUAUUGUUUAAAGGCCUGGUGUUGGGUAG 
Kluyveromyces wickerhamii    AUGGAGCCAGUACCUUAUCGCCACUUUUCGAUUGACACCAAAGCUCCCACAACGCGAACGUGAAACGCAUGACUGUUCU----------------------------------------- 
Kluyveromyces nonfermentans  UAGAUAGAGGCGGUUUUGGAACCUCACCUGAUGUACUCUUUCAAAUAUUC-UGUGAUAUU-----ACAAUGUUGCCCUUAGUGAUUG---CAUGUGACCUGUUUUGCGGGAGAAGCGGAC 
Kluyveromyces marxianus      CAAAGCUUUAGAUAUACCUGGC--------------------------------------------------------------------AUGCUAGAUCGUAUGCAUAUAUUUACGGAU 
Kluyveromyces dobzhanskii    AGGUGUGCAUGUUUGUGUGUUUGACGACAUAGUCCCAUUCGUGUAUCUGACAUACCAGAAGUACACGGAAGGAAACUGAGUUUGUUGAAUGAAGUGAGGUGCAGCCACACAGCGAUCAAA 
Kluyveromyces aestuarii      UAAUUGGGGGCGGUUUUGAACCCUGGCCUGAUAGUUCCUUCAAAAGGUGCAUUUGAUUCUCACGUACAACUUCGCCUCACCCCAUUGAAGUUUGCCAGUAAUUCAGCUAAAUAAGCGGAC 

                                     370       380       390       400       410       420       430       440       450       460       470       480           
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                                      
structure                                                                                                                                             
Kluyveromyces lactis         UAUUUCUAACGGAUUUUAGAAAUGCUAUGACAACAAUACCUUUAGAAUUAUAUUGUGUGGAUAUUUACUUCUUGUUAAACAGACUGUGACAUAUCUCAAUGAGAGGGGAUUAUUCUCGUU 
Kluyveromyces wickerhamii    ---------------------AUGCACUGUUUAUUUACAAAGCAUUCGGAAAAUACGAUGUAAAUAUGAGGUGUACGCACAAAGUUGUCGAUUGUAAAUGACCUAUCUAACUCAGUUCUA 
Kluyveromyces nonfermentans  CUUACGACGCUGAAUAGGAAAAUUAGUUUGAACUAAUAUUAUAUCACAUGGAGUUUCAAGGGGUGGAUAAGGUAGCAGUCUAACUGCCUGUCAGGGUAUCAUAUGGAAGUGUAUAUCA-G 
Kluyveromyces marxianus      UAAAGAUAUGUGUAUGAAUAUGGCGCUAGGAAUUUUGUGCUUAAAAGAGAGUUUGCGUUUAA-UAGGUCUUUCGCAGACUAUACCGGAUAAUACCAAUUUCGGAGGCAUGAGGAUUGGGG 
Kluyveromyces dobzhanskii    CCAGUGCUGUUGUUCGGUGCUUCUGACGGAUUUGGAAAACCUGAAUUGAUACGUGCCUUUUGAAAUUUUACUGGGUUGCAGUGUACCUUACUUUACCAGACUGACUCUUGUCUCGAUGGG 
Kluyveromyces aestuarii      CUUACGAAACUGAACUCAGGCAAACUC-CCUGUAUGAAAAUGAC--UGCUUGGAGCUGUUUGGA-UGAAGAAUGUAAGGGAUAGAUCUUAUGCAAUUGCCUUG---AGAAGUGAACUUCA 

                                     490       500       510       520       530       540       550       560       570       580       590       600           
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                    Template                          
structure                                                                                                ||||||||||||||||||||||||||||||               
Kluyveromyces lactis         UUUGGAGUUAUUCUGAUGCCUGUUGCUCUUGCUCCUACGCAUAGAAGCAUAGCAUUGAACUCCAUGGUGUGGUACUUCAAAUCCGUACACCACAUACCUAAUCAAAACCUCCUC-GCAAC 
Kluyveromyces wickerhamii    UAGGCCUUACACAUGUUUCAAACCUUGGUCUAGCUUUAAUAUGGUGCAGUGCGAAGAGUUAACAGAUUUGGUACUAU-AAAUCCGUACACCACAUACCUAAUCAAAACCGCCUU-AGAAC 
Kluyveromyces nonfermentans  GUGUA-----------------------------------------------------------------------UCAAAUCCGUACACCACAUACCUAAUCAAUCCUUUUUUUAGGAC 
Kluyveromyces marxianus      AGGCUCGCGCUC-AGUUAGAGAUGGUUAAGC--UCUCAAUG-GGAGUUUA-CAUCCAUUUUAUAAACGUGGUACUUUCAAAUCCGUACACCACAUAACUAAUCAAAACCGCUUC-UAAAC 
Kluyveromyces dobzhanskii    GAAAUACUUUAGUAUUGAAGUUCUUUCAACGUUGCACUCUUGUGCACAAUGCCUGGAAUUGUAGCGUUGAUCUUCAUAGCAU-GGCACUUCAAAUCCGUACACCACAUACCUAAUCAAAA 
Kluyveromyces aestuarii      -GGUGUA---------------------------------------------------------------------UCAAAUCCGUACACCACAUACCUAAUCAAUCCUUUUU--GGAAC 

                                     610       620       630       640       650       660       670       680       690       700       710       720           
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                      |----CS2----|                                   
structure                                                                                             ((((((((( (((                                   
Kluyveromyces lactis         GGCUUCCAUAUUCUCGUCUGUAUUCAAUCG-UGGAUAGUGGUUUCAGCUCGACGUGGGUAUGCUAGUGACUCAGAGUUUGGAUGUACUA-GGUUUCAUAAG------------------- 
Kluyveromyces wickerhamii    GGUU---AAACUCUGGUGUGUUUC-AUUUG--GCACUGUGGUACGGCCGUUA----GCUACGGCUCUAAUUCAGGGUUUAGA----UCAAGUUUACAAACGGAU---------------- 
Kluyveromyces nonfermentans  AGCCGU--GUUUCUGUUUCAUUGACAACGA----AUAGCGGC-GGAUAAAGCCAGCACUAA--UCGGAAUUGAGGGUUUGGA----UCAAGGUUACAUCAG------------------- 
Kluyveromyces marxianus      GGCUUUAAA-UUCAUAUCUGUAUCAACUUGAGGGAUAGCGGCGUCGAUUCGA-AAGGGCAA--CAGUGAUUCAGGAUGUGGAAAAGUCAAGGUUGCAUAAG------------------- 
Kluyveromyces dobzhanskii    CCGCUUUGAAACGGCUCCCAUUCUCGUCUGUUUCUACCCUGGGAUAGUGUUUUCAAUUCGACGUGGGUAAGCUGCAGAUUCAGGGUUUGGGGCACUAGGUUGCAUAAGAUUUGCAGCAAC 
Kluyveromyces aestuarii      UGCCAU--AUUUUUUGUUCACUGGCAACCA----AAAGCGGCCAAAGAGGGCUAGCAUCAG--UUGGAAUUAAGGGUUUGGA----UCAAGGUUACACAAA------------------- 

                                     730       740       750       760       770       780       790       800       810       820       830       840           
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                  |------CS2------|   
structure                                                                                                                         )))))))     )))))   
Kluyveromyces lactis         ---------------------------------------------GAUACCCAACUG-------------GAAAUGUUGC-GGAAAUAUCACAUUCGUCCUUGCUCCAUUGUUAACUCAG 
Kluyveromyces wickerhamii    --------------------------------------AACUUGUGUUCUGCAGGU---------------AACUGUGACCAAGUUGCAUCACUUAUGCUUGAUUCUAUGGUUAACCCAG 
Kluyveromyces nonfermentans  -----------------------------------------------------------------------GAAGGUUUU--GCUUUCAUAUUUUCUUUGCGAAUCCAUGGUUAACCCCG 
Kluyveromyces marxianus      --------------------------------------GAUGCAUGAGAUGAAAUUC--------------AAAUGUGUCAAAAACUCCUCGUUCCAUCGUUAAUCCGGUGU-CAUUUAG 
Kluyveromyces dobzhanskii    AUUCAGUUUCCAUGUAUGGUGCGAAAAGGCAGUAAUACUGUAGGAGAAGGCUGAUCCUUAAUUUUUUAAGUUCAGCUGGAAUGUUGCCAUAAAAAUCACCAUUAUCCUGGCCCCAUUGUU 
Kluyveromyces aestuarii      -----------------------------------------------------------------------GAACAUUAC--AUUUUCACAUUUGCCUUGCAUUUCCAUGGUUAACCCAG 

                                     850       860       870       880       890       900       910       920       930       940       950       960           
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                                      
structure                                                                                                                                             
Kluyveromyces lactis         UGUC-ACUUUAGGUCCUAUGGGAAACAAUGUUGAGCUGAUGCAUU--UUUCCG-UACAGCCA--UUACCGUUCUUCGGGAUGGCAAGGAUUAGCCCUUCCUAUUACAGGCUUUAUAAUGG 
Kluyveromyces wickerhamii    UGUG-AGAGUUGUUACAAUUAAUUUAUAUG-CGAUGAGCUGUUCUUUGAUCUG-UCAUACCAUGUU-UCGUUCUUCGUCAUGGAAAGGAU--AUCCCAGCCGUUACACACUUU------- 
Kluyveromyces nonfermentans  UGUU----UUGAUCGGUAUGAAAAAGU-UGUCCAACGGGAAAGUACAGAAACC-UUUAUUCAACAUUUGAUAAAAUGAAUUGAUGGAAAUCUGGC---ACCGUUAUGAAAUUC------- 
Kluyveromyces marxianus      UGCCUAUCGCAAGAGACAAAAAAAACUG-AUCGAGUCGACAUUUUUUAAUUUGCUUGAGUCAUGUUUCUGUCCUUCAGUAUGACGAGAAUUAGCCCUUCCUGUUACAGAUUUUACGGCGG 
Kluyveromyces dobzhanskii    AACUCAGCGUCAUUGCAGUCCCAUGGGAAACAAUGUCGAAUAGUGUAUUAAUCUAACAAGCCAUAUUAUCGUUUUCCGAAAUGGUGAGGAUAGACCUUCCUGUUACAGA-UUUACAACGG 
Kluyveromyces aestuarii      UGUU----CUAACUGAUAUGAAAAAAU-UGCCUAACGGAAAAAUUCAGAUUCC-UUACUUCCUUCUUUGAUUGAAUGGAAUCGUAAAUCUCUGAC---ACCGUUGUGAACAUG------- 

                                     970       980       990       1000      1010      1020      1030      1040      1050      1060      1070      1080          
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                          CS3                                                                    CS3  
structure                                                               ((((((                                                                 )))))) 
Kluyveromyces lactis         AAAACUCU---UAAGAUAUAUUUCUAGGUUUUUUUCCAUGAC-AGAGAA-UUAAGCCUGUGGUUCAUGUUGAUAUUCCAGAAUACGCAACAAUUGCUGCGUAUUCGGUA--GGUUUCUUU 
Kluyveromyces wickerhamii    ----------------CA-------------------UGUUC-AAAGAG-UUUAGCCUGUGGUUCAGUUUCAUGAUUUCGUCAUUCAAUGAUGUAUUUCUCGUC-------GGUCUCUUU 
Kluyveromyces nonfermentans  -----------------AUCUUCUCCG--------GAAGAA--GAAGCA---CGUGCUGCGACGUCAUCACGGAGACAAUG-ACAUGUAUUCUAC----------------GACUUGUUU 
Kluyveromyces marxianus      ACUUUUUUCCUUUUCAUAUCUGUGAGAGGAAACCGCUAAGU--AAAAGAAUAAAGCCUGUGGUUCAUUUCCAUUGUCUCUUUUCUUCUAUUUCCAAAAGAAACAAUGGCAGGCCUCUUUU 
Kluyveromyces dobzhanskii    UGAAUU-------AGA-ACGUUUCUCG----UUCACCGCAAC-AGAGGA-UGGAGUCUGUGGUUCGUUUUCAUGA-UUCCAAAUGCAGCAGCCGUUGUUUCGUUUGGCA--GGUUUUUUU 
Kluyveromyces aestuarii      -----------------AUCUC---------------CUUAAU-GAGGA-AAAAAUAUGUGCCGAAAUCCC-UGA-UCUGGAAUUCCUUUAU-------------------GGCUCCUU- 
                                                                                                                                            <<<<<     

                                     1090      1100      1110      1120      1130      1140      1150      1160      1170      1180      1190      1200          
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                        CS4                                                                                                  CS4      
structure                    )     (((((((((((                                                                                           )))))))))))  
Kluyveromyces lactis         --UU--AGUGAUUUU--UCCAAACCCAUU--CUUCUCUUCGUUAGUAUAUUUGA-CUCGG----UUCUAUUUCAAUGUGUCGCAUUGAAAUAGAAAUCCUUUGUGCAU--AAAAUCAUU- 
Kluyveromyces wickerhamii    --UU--AGUGAUUUU--UCCAGGCUAUUA-------UUGAACUGUUAACAGCAA------------CUAAUUU-------------UAAAUAAG-----UUGGUG-AU--AAAAUCAUU- 
Kluyveromyces nonfermentans  U--UAU--UGAUUUUUC--AAAGUCCGUC----UUUGUCUUUUUCUGCUUUGGA-----------UCCAUU-----------------AGUAUA------UCCUCC--GAAAAAUCA--U 
Kluyveromyces marxianus      ---UAU--UGAUUUU--UCCAGGCCUGUAACUUUAACUCUGCUGUUAUUUCCCGCCCCACCGACUUCUAUUAAGCUUUAAGGUUUAUAAA-AGUCACUUUUCGUGCAU--AAAAUCA--U 
Kluyveromyces dobzhanskii    --UUAU--UGAUUUU--UCCAAACCUGUA--UUCCGUUAUGCUAGUGUGUUCGAAUUCGU----GUCUAUUUCAC------------AAAUAGAA-UCCUUCGUGCAU--AAAAUCA--U 
Kluyveromyces aestuarii      -UUUAU--UGAUUUUUC--AAAGCC--------UUUACCAUUUUUUGCUUUGGA-----------UCCCCCUC--------------AAGUAUA------UAGUUC--GAAAAAUCA--U 
                                                 >>>>>                                                                                                

                                     1210      1220      1230      1240      1250      1260      1270      1280      1290      1300      1310      1320          
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                                 CS5a 
structure                                                                                                                                        (((( 
Kluyveromyces lactis         -UACCUCAAC--UUUCCUCACCAAGUAUCUUUGAAUGUUUUGCUCCCAUCAAGAAAGAAAGAACUUCUACUACAACGAGUCAAUAUGCUAGCAUGGUGGAGGUACAGUUGUCCUAUGGUG 
Kluyveromyces wickerhamii    -UACCUCUAU-------UCAAC-----------------UUGGUUGAUCAUCGG-----UUCUUCCUUAUCG-----------UUUGUUAACAGGGGGUGCCUGUAAUG---UGGUAAUG 
Kluyveromyces nonfermentans  UCACCUCCUU------CUAAACU--------------------CUCUUCAUGCA-----UGUCUGUUUUA---------------UGAUCCAAAGCAGUUGGUACAAAUCUGAAGCAAUG 
Kluyveromyces marxianus      UUACCUCAAUCAUUUCCCCAACUCUUGGUAAAAUAGAAAAAAAACAAGCACCAGACAAUUUGAUCCAUAGGGAAAGGGAAACUUCUAUAACAACAGAGUAGGUACAGAGCACCUA-UGUG 
Kluyveromyces dobzhanskii    UUACCUCAAC--UCCCUUCACCAUUUGUCUUU-------UCGUUGAAAUAUCCACACUCUAAAUCCUUGUUGAAAUGA-----UACACUGGCAUGACCGAGGCACAGUGACUCUAUGGUA 
Kluyveromyces aestuarii      UCACCUCCACA-----UUAAACU--------------------CUCUUUAUGCA-----CGCAUUCAUGGC--------------UGAUCCAUAGCUACAGGUACAAGUUGAGCACGGUG 

                                     1330      1340      1350      1360      1370      1380      1390      1400      1410      1420      1430      1440          
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                             |-CS5b -|                          |---CS5b---| |--Sc6--|                                                                
structure                    (((((( ((                          ))))  )))))) ((((   ((                                                                
Kluyveromyces lactis         GAUCUU-GAAAAGACCCUCGGAAGACAGGGCCACAUCGA-C--GAUCAAUAUUUUGCCUAUCAUCAACAA-AUUGUGACUGAUUUUUCUCUCAUCGUUUAUGAGAGAACCCUCUUGUCUC 
Kluyveromyces wickerhamii    GAUCC-CAACAAGCCUUUCGGUU-AUAAGGCUGAAUU---CGGGUC-AAUAUUUUGCCAAUCAUUGGCA---UUUUUGUCAAUUGAA--------------------------------- 
Kluyveromyces nonfermentans  GAUCUC-GCAAAGAU--UCGGAU--UCAAAUUCU-UUG--CAGAUU-AAUAUUUCGCUAUACACAGACAACAUGAU-GUGUGUUGAU--------------------------------- 
Kluyveromyces marxianus      GGUCCUG-AAAAGACUUUCGAAAGAUUGAGUCG--U---AAAGGACUAAUAUUUUGCCUACCAUUAACAA-AAGACAAAAAAUCAAAGCAG-AUAGUU-----AAAUCUCUGUCAGAUUU 
Kluyveromyces dobzhanskii    AAUCUC-GAAAAGAUCCUCGGAAGAUAGGUUCACAUCGA-CGAUU--AAUAUUUUGCCUAUCAUCACCAA-AUCGCUACUGGUGUCUCCAUCGAUGU-------AGAACCUUUUAGCC-C 
Kluyveromyces aestuarii      AAUCUC-GCAAAAAAA-UCGGAU--UCAAAUUUU-UU---AGAGAUUAAUAUUUCGCAAUCGAUGGACAAUAAAAAAGUCUGUCGUU--------------------------------- 

                                     1450      1460      1470      1480      1490      1500      1510      1520      1530      1540      1550      1560          
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                |-CS6--|  CS5a                         Sm site                                                        
structure                                       ))  ))))  ))))                      |||||||||||||                                                     
Kluyveromyces lactis         UUGUGAUUGAC--------GCUUAUAUGUCACCAUGGCAUGCAGCUGCUCCUUAUAACCACUUUUUGGUACAUCUCCCUACUAAGACUCGGGAACUGUUGCACUUAUCAAUUUAUUCUUG 
Kluyveromyces wickerhamii    -------------------GCUUAUAUGUCAUUGCCAAUCAUUACGUUCCUUAU-AACUA-UUUUUGGACGUCUCU------------------------------------------   
Kluyveromyces nonfermentans  -------------------CCUUAUAUGUCAUUGUGUCUGGUUUGUUCCAUGU--AACCAUUUUUUGGAGUAUUGUUU----------------------------------------   
Kluyveromyces marxianus      UUUUCGUUUAUUAAUUGAUGCUUAUAUGUCAUUAUAGGCUUGCACUGUCCCUUAUAACCAUUUUUUGGCACCUAAACACACUUGCUUCAAGCAUCUUGAAUGUUUGAACAACCUUUUUUU 
Kluyveromyces dobzhanskii    UUGUGAUUGAC--------GCUUAUAUGCUACGAUAGAAUGUUACUGCACCGAA-AACCAAUUUUUGGAUAUUCUCCUUUG-------------------------------------   
Kluyveromyces aestuarii      -------------------GCUUAUAUGUCAGCGUGCUUGAUUUGUUCCAUAU--AACCAUUUUUUGGAAAAUUAUU-----------------------------------------   
                                                                                    |----CS7----|                                                     

                                     1570      1580      1590      1600      1610      1620      1630      1640      1650      1660      1670      1680          
                             ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
                                                                                                                                                      
structure                                                                                                                                             
Kluyveromyces lactis         AGAUAAGGGCAACA                                                                                                           
Kluyveromyces wickerhamii                                                                                                                             
Kluyveromyces nonfermentans                                                                                                                           
Kluyveromyces marxianus      CUUUUUAUUUUUCCUCUCUUGUUUGUAUAUUGUGUUUAACGUAUCCUUAGAGCCAUUGUGGCGCUUUGUCGGCUCGCCGUAGACACAUCUUAUCAAAUCACUUUUAUCAGCUCUUGAUGU 
Kluyveromyces dobzhanskii                                                                                                                             
Kluyveromyces aestuarii                                                                                                                               

                                     1690     
                             ....|....|....|..
                                               
structure                                      
Kluyveromyces lactis                           
Kluyveromyces wickerhamii                      
Kluyveromyces nonfermentans                    
Kluyveromyces marxianus      AGUCUGCUGUUAUCGAU 
Kluyveromyces dobzhanskii                      
Kluyveromyces aestuarii